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Optimization of an ether series of mGlu5 positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover

Jason Manka, Paige N. Vinson, Karen J. Gregory, Ya Zhou, Richard D. Williams, Kiran K. Gogi, Emily Days, Satya Jadhav, Elizabeth J. Herman, Hilde Lavreysen,

Bioorganic & Medicinal Chemistry Letters · 2012 · 12 citations · 24 references

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24

A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

Gene G. Kinney, Julie A. O’Brien, Wei Lemaire et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 299 citations

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Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery

Bruce J. Melancon, Corey R. Hopkins, Michael R. Wood et al. · Journal of Medicinal Chemistry · 2011 · 223 citations · Full text

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A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5

Julie A. O’Brien, Wei Lemaire, Tsing‐Bau Chen et al. · Molecular Pharmacology · 2003 · 209 citations

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Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

Alice L. Rodriguez, Mark D. Grier, Carrie K. Jones et al. · Molecular Pharmacology · 2010 · 179 citations · Full text

, , +17

A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain

Julie A. O’Brien, Wei Lemaire, Marion Wittmann et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 172 citations

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