Wei Lemaire

Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Christopher D. Cox, Michael J. Breslin, David B. Whitman et al. · Journal of Medicinal Chemistry · 2010 · 367 citations · Full text

Psychotropic Medication, Pharmacotherapy, Primary Insomnia +17

A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

Gene G. Kinney, Julie A. O’Brien, Wei Lemaire et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 298 citations

A Family of Highly Selective Allosteric Modulators of the Metabotropic Glutamate Receptor Subtype 5

Julie A. O’Brien, Wei Lemaire, Tsing‐Bau Chen et al. · Molecular Pharmacology · 2003 · 209 citations

A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain

Julie A. O’Brien, Wei Lemaire, Marion Wittmann et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 172 citations

Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of <i>N</i>-(1,3-Diphenyl-1<i>H</i>- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo

Craig W. Lindsley, David D. Wisnoski, William Leister et al. · Journal of Medicinal Chemistry · 2004 · 170 citations · Full text

Synaptic Transmission, Pharmacotherapy, Active Allosteric Modulators +20