Michael J. Breslin

Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Christopher D. Cox, Michael J. Breslin, David B. Whitman et al. · Journal of Medicinal Chemistry · 2010 · 367 citations · Full text

Psychotropic Medication, Pharmacotherapy, Primary Insomnia +17

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

Christopher J. Winrow, Anthony L. Gotter, Christopher D. Cox et al. · Journal of Neurogenetics · 2011 · 266 citations

Sleep Disorders, Sleep Medicine, Sleep +13

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2<i>S</i>)-4-(2,5-Difluorophenyl)-<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-<i>N</i>-methyl-2-phenyl-2,5-dihydro-1<i>H</i>-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Christopher D. Cox, Paul J. Coleman, Michael J. Breslin et al. · Journal of Medicinal Chemistry · 2008 · 156 citations · Full text

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP

Christopher D. Cox, Michael J. Breslin, Brenda J. Mariano et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 136 citations · Full text

Protein Function, Biochemistry, Natural Sciences +10

Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

Christopher J. Winrow, Anthony L. Gotter, Christopher D. Cox et al. · Neuropharmacology · 2011 · 123 citations

Molecular Pharmacology, Pharmacological Characterization, Medicine +7