John D. Schreier

Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Christopher D. Cox, Michael J. Breslin, David B. Whitman et al. · Journal of Medicinal Chemistry · 2010 · 367 citations · Full text

Psychotropic Medication, Pharmacotherapy, Primary Insomnia +17

Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia

Christopher J. Winrow, Anthony L. Gotter, Christopher D. Cox et al. · Neuropharmacology · 2011 · 123 citations

Molecular Pharmacology, Pharmacological Characterization, Medicine +7

Discovery of [(2<i>R</i>,5<i>R</i>)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties

Paul J. Coleman, John D. Schreier, Christopher D. Cox et al. · ChemMedChem · 2012 · 121 citations

Sleep Disorders, Neurotransmitter, Peptide Science +19

The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey

Sean M. Smith, Jason M. Uslaner, Christopher D. Cox et al. · Neuropharmacology · 2012 · 84 citations · Full text

Inhibitor Thpp-1, Novel Phosphodiesterase 10A, Behavioral Neuroscience +11

CO Cross‐Coupling of Activated Aryl and Heteroaryl Halides with Aliphatic Alcohols

Peter E. Maligres, Jing Li, Shane W. Krska et al. · Angewandte Chemie International Edition · 2012 · 84 citations