Concepedia

Positive Allosteric Modulation

Positive Allosteric Modulation is an academic concept in enzymology and pharmacology denoting a type of allosteric regulation wherein a ligand binds to an allosteric site on a protein to enhance its activity by increasing the affinity or efficacy of the primary ligand at its active site.

1.1K

Publications

57.2K

Citations

6.1K

Authors

1.2K

Institutions

Publications per year

2017–2026

408

Parents

Publications

1.1K

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density

Kellie S. Gross, Dieter D. Brandner, Luis A. Martinez et al. · PLoS ONE · 2016 · 1.6K citations · Full text

, , +17

Calcimimetics with potent and selective activity on the parathyroid calcium receptor

Edward F. Nemeth, Michael E. Steffey, Lance G. Hammerland et al. · Proceedings of the National Academy of Sciences · 1998 · 612 citations

, , +17

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

Fong‐Sen Wu, Terrell T. Gibbs, David H. Farb · Molecular Pharmacology · 1991 · 530 citations

, , +17

Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA<sub>A</sub> receptors and a homo‐oligomeric GABA receptor from <i>Drosophila melanogaster</i>

Caroline M. Priestley, Elizabeth M. Williamson, Keith A. Wafford et al. · British Journal of Pharmacology · 2003 · 498 citations · Full text

, , +17

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Rafael Moliner, Mykhailo Girych, Cecilia A. Brunello et al. · Nature Neuroscience · 2023 · 432 citations · Full text

, , +17

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Authors

6.1K

  1. PJ
    P. Jeffrey Conn

    Vanderbilt University, United States

    83 publications · 5.8K citations

    48

    h-index

  2. CW
    Craig W. Lindsley

    Vanderbilt University, United States

    78 publications · 5.1K citations

    45

    h-index

  3. CM
    Colleen M. Niswender

    Vanderbilt University, United States

    53 publications · 3K citations

    34

    h-index

  4. CK
    Carrie K. Jones

    Vanderbilt University, United States

    39 publications · 2.4K citations

    30

    h-index

  5. AC
    Arthur Christopoulos

    Monash University, Australia

    37 publications · 2.2K citations

    26

    h-index

1–5 of 6.1K

Institutions

1.2K

  1. Vanderbilt University Medical Center

    Nashville, United States

    37 h-index

    445 publications

    25.9K citations

  2. Vanderbilt University

    Nashville, United States

    36 h-index

    489 publications

    27K citations

  3. Monash University

    Melbourne, Australia

    28 h-index

    307 publications

    15.2K citations

  4. Janssen (Belgium)

    Beerse, Belgium

    22 h-index

    208 publications

    11K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    22 h-index

    167 publications

    9.4K citations

  6. United States Military Academy

    West Point, United States

    20 h-index

    242 publications

    16.1K citations

  7. University of Copenhagen

    Copenhagen, Denmark

    19 h-index

    113 publications

    3.7K citations

  8. Inserm

    Paris, France

    18 h-index

    96 publications

    6.4K citations

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Venues

  1. Journal of Medicinal Chemistry

    93 publications · 4K citations

    40

    h-index

  2. Molecular Pharmacology

    68 publications · 5.6K citations

    39

    h-index

  3. British Journal of Pharmacology

    BJP · 57 publications · 3.3K citations

    35

    h-index

  4. 33

    h-index

  5. Neuropharmacology

    46 publications · 2.3K citations

    29

    h-index

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