Allosteric Regulation is a biochemical mechanism whereby the binding of an effector molecule at an allosteric site on a protein molecule induces a conformational change that modulates the protein’s functional activity at a distinct active site.
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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
J.M. Ostrem, Ulf Peters, Martin L. Sos et al. · Nature · 2013 · 2.5K citations · Full text
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
Xuewu Zhang, Jodi Gureasko, Kui Shen et al. · Cell · 2006 · 1.6K citations · Full text
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