Structural Bioinformatics

Structural Bioinformatics is a subdiscipline of bioinformatics that applies computational methods to the analysis, prediction, and modeling of three-dimensional structures of biological macromolecules.

19.8K

Publications

2.7M

Citations

47.9K

Authors

6.5K

Institutions

Publications per year

2017–2026

5.5K

Parents

Bioinformatics

Children

Allosteric RegulationComparative ModelingHomology ModelingMembrane Protein TopologyMolecular DockingNucleic Acid StructureProtein DesignProtein DynamicsProtein Fold RecognitionProtein Structure

Publications

19.8K

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Julie Thompson, Desmond G. Higgins, Toby J. Gibson · Nucleic Acids Research · 1994 · 64.9K citations · Full text

Life Sciences, Bioinformatics, Sequence Analysis +14

UCSF Chimera—A visualization system for exploratory research and analysis

Eric F. Pettersen, Thomas D. Goddard, Conrad C. Huang et al. · Journal of Computational Chemistry · 2004 · 47.8K citations

Computing, Bioinformatics, Visualization +17

Highly accurate protein structure prediction with AlphaFold

John Jumper, Alexander Pritzel, Tim Green et al. · Nature · 2021 · 45.2K citations · Full text

Life Sciences, Biochemistry, Bioinformatics +11

The Protein Data Bank

Helen M. Berman · Nucleic Acids Research · 2000 · 39.8K citations

Life Sciences, Biochemistry, Bioinformatics +10

<i>Coot</i>: model-building tools for molecular graphics

Paul Emsley, Kevin Cowtan · Acta Crystallographica Section D Biological Crystallography · 2004 · 31.4K citations · Full text

Life Sciences, Bioinformatics, Biology +17

1–5 of 19.8K

Authors

47.9K

DB
David Baker
University of Washington, United States
150 publications · 40K citations
81
h-index
YZ
Yang Zhang
University of Michigan, United States
135 publications · 39.8K citations
72
h-index
JM
Janet M. Thornton
University College London, United Kingdom
105 publications · 49.9K citations
70
h-index
BR
Burkhard Rost
Columbia University, United States
102 publications · 22.3K citations
65
h-index
AŠ
Andrej Šali
University of California, San Francisco, United States
87 publications · 46.3K citations
56
h-index

1–5 of 47.9K

Institutions

6.5K

1–8 of 6.5K

Venues

Nucleic Acids Research
1.7K publications · 567.3K citations
291
h-index
Bioinformatics
1.5K publications · 218.3K citations
196
h-index
Proteins Structure Function and Bioinformatics
1.4K publications · 141K citations
172
h-index
Journal of Molecular Biology
JMB · 565 publications · 155.7K citations
155
h-index
Proceedings of the National Academy of Sciences
PNAS · 327 publications · 69.6K citations
120
h-index

1–5

See also Structural Bioinformatics
Core Methods	Protein Structure Prediction Molecular Docking Molecular Simulation Homology Modeling Dynamic Programming Structural Alignment Fragment Assembly Protein Threading Structure Superposition
Applications	Protein Structure Prediction Virtual Screening Functional Annotation Target Identification Allosteric Drug Design Computational Drug Discovery Precision Medicine Active Site Analysis
Data Resources	Structural Bioinformatics
Evaluation	Root-mean-square Deviation
Limitations	Protein Folding Simulations Proteome-wide Structure Determination Data Interoperability