Concepedia

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

J.M. Ostrem, Ulf Peters, Martin L. Sos, James A. Wells, Kevan M. Shokat

Nature · 2013 · 2.5K citations · 32 references

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32

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A. Barbie, Pablo Tamayo, Jesse S. Boehm et al. · Nature · 2009 · 4.2K citations · Full text

, , +13

<i>KRAS</i> Mutation Status Is Predictive of Response to Cetuximab Therapy in Colorectal Cancer

Astrid Lièvre, Jean‐Baptiste Bachet, Delphine Le Corre et al. · Cancer Research · 2006 · 2.2K citations

, , +17

KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib

William Pao, Theresa Y. Wang, Gregory J. Riely et al. · PLoS Medicine · 2005 · 1.5K citations · Full text

, , +15

A Cytoplasmic Protein Stimulates Normal N- <i>ras</i> p21 GTPase, But Does Not Affect Oncogenic Mutants

Meg Trahey, Frank McCormick · Science · 1987 · 1.2K citations

, , +13

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic <i>ras</i> Proteins

Michael V. Milburn, Liang Tong, Abraham M. deVos et al. · Science · 1990 · 1.1K citations

, , +17