Kevan M. Shokat

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

David E. Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou et al. · Nature · 2020 · 4.8K citations · Full text

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

J.M. Ostrem, Ulf Peters, Martin L. Sos et al. · Nature · 2013 · 2.4K citations · Full text

Molecular Pharmacology, Signal Transduction, G Protein-coupled Receptor +7

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag et al. · Nature · 2010 · 1.8K citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +10

IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

Jonathan H. Lin, Han Li, Douglas Yasumura et al. · Science · 2007 · 1.4K citations

Apoptosis, Molecular Biology, Cell Death +17

The translational landscape of mTOR signalling steers cancer initiation and metastasis

Andrew C. Hsieh, Yi Liu, Merritt P. Edlind et al. · Nature · 2012 · 1.3K citations · Full text

Tumor Biology, Signal Transduction, Signaling Pathway +10