Poulikos I. Poulikakos

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag et al. · Nature · 2010 · 1.8K citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +15

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

Poulikos I. Poulikakos, Yogindra Persaud, Manickam Janakiraman et al. · Nature · 2011 · 1.4K citations

Medicine, Molecular Biology, Oncology +9

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas

Piro Lito, Christine A. Pratilas, Eric W. Joseph et al. · Cancer Cell · 2012 · 566 citations · Full text

Medicine, Cancer Biology, Oncology +17

BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition

Zhan Yao, Neilawattie M. Torres, Anthony Tao et al. · Cancer Cell · 2015 · 546 citations

Medicine, Cancer Biology, Oncology +17

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

Eric W. Joseph, Christine A. Pratilas, Poulikos I. Poulikakos et al. · Proceedings of the National Academy of Sciences · 2010 · 447 citations · Full text

Medicine, Cancer Biology, Oncology +15