Eric W. Joseph

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas

Piro Lito, Christine A. Pratilas, Eric W. Joseph et al. · Cancer Cell · 2012 · 566 citations · Full text

Medicine, Cancer Biology, Oncology +17

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

Eric W. Joseph, Christine A. Pratilas, Poulikos I. Poulikakos et al. · Proceedings of the National Academy of Sciences · 2010 · 447 citations · Full text

Medicine, Cancer Biology, Oncology +15

Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

Piro Lito, Anna Saborowski, Jingyin Yue et al. · Cancer Cell · 2014 · 312 citations · Full text

Medicine, Cancer Biology, Oncology +14

Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Nobuya Ishii, Naoki Harada, Eric W. Joseph et al. · Cancer Research · 2013 · 166 citations

Medicine, Oncology, Pharmacology +16

P-347 A phase 3, randomized, double-blind, placebo-controlled study of transarterial chemoembolization combined with durvalumab or durvalumab plus bevacizumab therapy in patients with locoregional hepatocellular carcinoma: EMERALD-1

Bruno Sangro, Masatoshi Kudo, Shukui Qin et al. · Annals of Oncology · 2020 · 33 citations · Full text

Medicine, Oncology, Pharmacotherapy +15