Christine A. Pratilas

BRAF mutation predicts sensitivity to MEK inhibition

David B. Solit, Levi A. Garraway, Christine A. Pratilas et al. · Nature · 2005 · 1.3K citations · Full text

Signal Transduction, Braf Mutation, Genetic Disorder +6

^V600E BRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway

Christine A. Pratilas, Barry S. Taylor, Qing Ye et al. · Proceedings of the National Academy of Sciences · 2009 · 611 citations · Full text

Molecular Regulation, Transcriptional Output, Genetics +17

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas

Piro Lito, Christine A. Pratilas, Eric W. Joseph et al. · Cancer Cell · 2012 · 551 citations · Full text

Signal Transduction, Cell Regulation, Medicine +11

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

Eric W. Joseph, Christine A. Pratilas, Poulikos I. Poulikakos et al. · Proceedings of the National Academy of Sciences · 2010 · 446 citations · Full text

Loss of NF1 in Cutaneous Melanoma Is Associated with RAS Activation and MEK Dependence

Moriah H. Nissan, Christine A. Pratilas, Alexis M. Jones et al. · Cancer Research · 2014 · 303 citations · Full text

Pathology, Dermatology, Tumor Biology +20