Piro Lito

KRAS ^G12C Inhibition with Sotorasib in Advanced Solid Tumors

David S. Hong, Marwan Fakih, John H. Strickler et al. · New England Journal of Medicine · 2020 · 1.7K citations · Full text

Medicine, Oncology, Oncogenes +1

The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients

Jill Hallin, Lars D. Engstrom, Lauren Hargis et al. · Cancer Discovery · 2019 · 1.3K citations · Full text

Medicine, Oncology, Pharmacology +17

Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

Piro Lito, Martha Solomon, Lian‐Sheng Li et al. · Science · 2016 · 685 citations · Full text

Medicine, Oncology, Pharmacology +17

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas

Piro Lito, Christine A. Pratilas, Eric W. Joseph et al. · Cancer Cell · 2012 · 566 citations · Full text

Medicine, Cancer Biology, Oncology +17

Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

Jenny Y. Xue, Yulei Zhao, Jordan Aronowitz et al. · Nature · 2020 · 546 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8