Lian‐Sheng Li

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

Matthew R. Janes, Jingchuan Zhang, Lian‐Sheng Li et al. · Cell · 2018 · 1.1K citations · Full text

Kras Mutant Cancers, Medicine, Anti-cancer Agent +6

Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State

Matthew P. Patricelli, Matthew R. Janes, Lian‐Sheng Li et al. · Cancer Discovery · 2016 · 731 citations · Full text

Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

Piro Lito, Martha Solomon, Lian‐Sheng Li et al. · Science · 2016 · 659 citations · Full text

Gtpase Activity, Signal Transduction, Biochemistry +15

KRAS G12C NSCLC Models Are Sensitive to Direct Targeting of KRAS in Combination with PI3K Inhibition

Sandra Misale, Jackson P. Fatherree, Eliane Cortez et al. · Clinical Cancer Research · 2018 · 253 citations

PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models

David G. Winkler, L. Kerrie, Jonathan P. DiNitto et al. · Chemistry & Biology · 2013 · 250 citations

Immunology, Immune Regulation, Immune System +19