David G. Winkler

PI3Kγ is a molecular switch that controls immune suppression

Megan M. Kaneda, Karen Messer, Natacha Ralainirina et al. · Nature · 2016 · 1.2K citations

Life Sciences, Immunology, Molecular Biology +14

PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models

David G. Winkler, Jonathan P. DiNitto, Janid A. Ali et al. · Chemistry & Biology · 2013 · 258 citations

Life Sciences, Immunology, Pathology +15

Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation

May Kung Sutherland, James C. Geoghegan, Changpu Yu et al. · Bone · 2004 · 239 citations

Medicine, Cell Biology, Endocrinology +14

Sclerostin Inhibition of Wnt-3a-induced C3H10T1/2 Cell Differentiation Is Indirect and Mediated by Bone Morphogenetic Proteins

David G. Winkler, May S.K. Sutherland, Ethan W. Ojala et al. · Journal of Biological Chemistry · 2004 · 164 citations · Full text

Life Sciences, Developmental Biology, Bone Metabolism +16

Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate

Catherine A. Evans, Tao Liu, André Lescarbeau et al. · ACS Medicinal Chemistry Letters · 2016 · 151 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +11