Chao Zhang

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag, Peter Hirth, James Tsai et al. · Nature · 2010 · 1.8K citations

Medicine, Oncology, Pharmacology +14

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag et al. · Nature · 2010 · 1.8K citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +15

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai, John Tayu Lee, Weiru Wang et al. · Proceedings of the National Academy of Sciences · 2008 · 1.3K citations · Full text

Medicine, Oncology, Pharmacology +15

Determination of atomic desolvation energies from the structures of crystallized proteins

Chao Zhang, George Vasmatzis, James Cornette et al. · Journal of Molecular Biology · 1997 · 549 citations · Full text

Natural Sciences, Biochemistry, Biophysics +17

Structural Bioinformatics-Based Design of Selective, Irreversible Kinase Inhibitors

Michael S. Cohen, Chao Zhang, Kevan M. Shokat et al. · Science · 2005 · 508 citations · Full text

Life Sciences, Bioinformatics, Medicinal Chemistry +15