James Tsai

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag, Peter Hirth, James Tsai et al. · Nature · 2010 · 1.8K citations

Medicine, Oncology, Pharmacology +14

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai, John Tayu Lee, Weiru Wang et al. · Proceedings of the National Academy of Sciences · 2008 · 1.3K citations · Full text

Medicine, Oncology, Pharmacology +15

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

Eric W. Joseph, Christine A. Pratilas, Poulikos I. Poulikakos et al. · Proceedings of the National Academy of Sciences · 2010 · 447 citations · Full text

Medicine, Cancer Biology, Oncology +15

RAF inhibitors that evade paradoxical MAPK pathway activation

Chao Zhang, Wayne Spevak, Ying Zhang et al. · Nature · 2015 · 381 citations

Life Sciences, Cancer Biology, Oncology +14

Herceptin and Gemcitabine for Metastatic Pancreatic Cancers That Overexpress HER-2/<i>neu</i>

Howard Safran, David A. Iannitti, Ramesh K. Ramanathan et al. · Cancer Investigation · 2004 · 190 citations

Medicine, Oncology, Pharmacology +16