Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai, John Tayu Lee, Weiru Wang, +35

Proceedings of the National Academy of Sciences

Diverse somatic mutation patterns and pathway alterations in human cancers

Zhengyan Kan, Bijay S. Jaiswal, Jeremy Stinson, +29

Nature

Cancer ResearchEngineeringPathway AlterationsSomatic VariantTumor Heterogeneity +8

Recurrent R-spondin fusions in colon cancer

Somasekar Seshagiri, Eric Stawiski, Steffen Durinck, +24

Nature

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Till Maurer, Lindsay S. Garrenton, Angela Oh, +16

Proceedings of the National Academy of Sciences

Distinct PocketMolecular BiologyRas GeneSmall-molecule LigandsCancer Biology +19

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

Kunxin Luo, Shannon L. Stroschein, Weiru Wang, +4

Genes & Development

RAF inhibitors that evade paradoxical MAPK pathway activation

Chao Zhang, Wayne Spevak, Ying Zhang, +32

Nature

Signaling PathwayMedicineReceptor Tyrosine KinaseMechanism Of ActionRaf Inhibitors +3

Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes

Steffen Durinck, Eric Stawiski, Andrea Pavía-Jiménez, +38

Nature Genetics

UrologyDiverse Genomic AlterationsGenitourinary CancerTumor HeterogeneityMedicine +5

Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

Bijay S. Jaiswal, Vasantharajan Janakiraman, Noelyn M. Kljavin, +20

Cancer Cell

Somatic VariantSomatic MutationsCell RegulationGeneticsP85α Promote Tumorigenesis +6

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

Jasvinder K. Atwal, Yongmei Chen, Cecilia Chiu, +17

Science Translational Medicine

An ARL3–UNC119–RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium

Kevin J. Wright, Lisa M. Baye, Anique Olivier-Mason, +9

Genes & Development

Molecular RegulationMolecular BiologyPrimary CiliumSynaptic SignalingCellular Physiology +16