Somasekar Seshagiri

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Ingrid E. Wertz, Karen O’Rourke, Honglin Zhou et al. · Nature · 2004 · 1.8K citations

Life Sciences, Cell Biology, Molecular Biology +12

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou, Kyung Song, Ivana Yen et al. · Nature · 2010 · 1.6K citations

Medicine, Cancer Biology, Oncology +15

Mutations in the Epidermal Growth Factor Receptor and in KRAS Are Predictive and Prognostic Indicators in Patients With Non–Small-Cell Lung Cancer Treated With Chemotherapy Alone and in Combination With Erlotinib

David A. Eberhard, Bruce E. Johnson, Lukas C. Amler et al. · Journal of Clinical Oncology · 2005 · 1.5K citations · Full text

Medicine, Oncology, Pharmacology +17

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

Charles M. Rudin, Steffen Durinck, Eric Stawiski et al. · Nature Genetics · 2012 · 1.1K citations

Medicine, Genetics, Molecular Genetics +12

Diverse somatic mutation patterns and pathway alterations in human cancers

Zhengyan Kan, Bijay S. Jaiswal, Jeremy Stinson et al. · Nature · 2010 · 1K citations

Medicine, Genetics, Oncology +16