Ivana Yen

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou, Kyung Song, Ivana Yen et al. · Nature · 2010 · 1.6K citations

Medicine, Cancer Biology, Oncology +15

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Aaron Boudreau, Hans E. Purkey, A. Hitz et al. · Nature Chemical Biology · 2016 · 268 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling

Jacob R. Haling, Jawahar Sudhamsu, Ivana Yen et al. · Cancer Cell · 2014 · 253 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

Scott A. Foster, Daniel M. Whalen, Ayşegül Özen et al. · Cancer Cell · 2016 · 216 citations · Full text

Medicine, Genetics, Oncology +14

ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma

Ivana Yen, Jeeyun Lee, Yong Sang Hong et al. · Nature · 2021 · 135 citations · Full text

Medicine, Oncology, Pharmacology +14