Daniel M. Whalen

Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS

Christopher J. Schulze, Kyle J. Seamon, Yulei Zhao et al. · Science · 2023 · 232 citations · Full text

Medicine, Medicinal Chemistry, Oncology +17

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

Scott A. Foster, Daniel M. Whalen, Ayşegül Özen et al. · Cancer Cell · 2016 · 216 citations · Full text

Medicine, Genetics, Oncology +14

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

Sigrid Nachtergaele, Daniel M. Whalen, Laurel K. Mydock et al. · eLife · 2013 · 165 citations · Full text

Life Sciences, Molecular Biology, Oncology +14

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

Stephen C. Graham, Mohammad W. Bahar, Samantha Cooray et al. · PLoS Pathogens · 2008 · 155 citations · Full text

Life Sciences, Biology, Molecular Biology +16

Structural insights into proteoglycan-shaped Hedgehog signaling

Daniel M. Whalen, Tomas Malinauskas, Robert J.C. Gilbert et al. · Proceedings of the National Academy of Sciences · 2013 · 105 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17