Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang, Hengyou Weng, Wenju Sun, +27

Nature Cell Biology

EngineeringRna Binding ProteinsMrna StabilityRna BiologyMolecular Biology +8

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase

Zejuan Li, Hengyou Weng, Rui Su, +26

Cancer Cell

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R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Su, Lei Dong, Chenying Li, +29

Cell

Tumor BiologyMedicineTumor SuppressorCancer BiologyCell Biology +1

The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA

Dan Dominissini, Sigrid Nachtergaele, Sharon Moshitch-Moshkovitz, +17

Nature

ChromatinNatural SciencesRna Structure PredictionEpigenomicsMolecular Biology +5

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

Yang Xiang, Benoît Laurent, Chih-Hung Hsu, +13

Nature

Structural basis of Smoothened regulation by its extracellular domains

Eamon F.X. Byrne, Ria Sircar, Paul S. Miller, +11

Nature

Signal TransductionMolecular PhysiologyMolecular RegulationCellular Regulatory MechanismCytoskeleton +8

Oxysterols are allosteric activators of the oncoprotein Smoothened

Sigrid Nachtergaele, Laurel K. Mydock, Kathiresan Krishnan, +4

Nature Chemical Biology

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Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

Giovanni Luchetti, Ria Sircar, Jennifer H. Kong, +6

eLife

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Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA

Huiqing Zhou, Simone Rauch, Qing Dai, +6

Nature Methods

Natural SciencesGeneticsRna BiologyMolecular BiologyReverse Transcriptase +8

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

Sigrid Nachtergaele, Daniel M. Whalen, Laurel K. Mydock, +7

eLife