Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang, Hengyou Weng, Wenju Sun, +27

Nature Cell Biology

EngineeringRna Binding ProteinsMrna StabilityRna BiologyMolecular Biology +8

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase

Zejuan Li, Hengyou Weng, Rui Su, +26

Cancer Cell

N 6ChromatinNatural SciencesAcute Myeloid LeukemiaMixed-phenotype Acute Leukemia +8

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Su, Lei Dong, Chenying Li, +29

Cell

Tumor BiologyMedicineTumor SuppressorCancer BiologyCell Biology +1

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

Hengyou Weng, Huilin Huang, Huizhe Wu, +26

Cell stem cell

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaImmunologyStem Cell Research +7

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Rui Su, Lei Dong, Yangchan Li, +36

Cancer Cell

Immune EvasionMedicineStem Cell MobilizationImmunologyStem Cell Research +6

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

Huilin Huang, Hengyou Weng, Keren Zhou, +39

Nature

Histone ModificationsChromatinTranscriptional RegulationChromatin StructureChromatin Remodeling +12

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

Chao Shen, Yue Sheng, Allen Zhu, +21

Cell stem cell

Systems BiologyMedicineAcute Myeloid LeukemiaMixed-phenotype Acute LeukemiaStem Cell Research +7

The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia

Hengyou Weng, Feng Huang, Zhaojin Yu, +31

Cancer Cell

Hematological MalignancyGlutamine MetabolismMedicineAcute Myeloid LeukemiaMixed-phenotype Acute Leukemia +6

miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

Xi Jiang, Chao Hu, Stephen Arnovitz, +27

Nature Communications

Overexpression and knockout of miR-126 both promote leukemogenesis

Zejuan Li, Ping Chen, Rui Su, +22

Blood