Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang, Hengyou Weng, Wenju Sun, +27

Nature Cell Biology

EngineeringRna Binding ProteinsMrna StabilityRna BiologyMolecular Biology +8

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase

Zejuan Li, Hengyou Weng, Rui Su, +26

Cancer Cell

N 6ChromatinNatural SciencesAcute Myeloid LeukemiaMixed-phenotype Acute Leukemia +8

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Su, Lei Dong, Chenying Li, +29

Cell

Tumor BiologyMedicineTumor SuppressorCancer BiologyCell Biology +1

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

Hengyou Weng, Huilin Huang, Huizhe Wu, +26

Cell stem cell

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaImmunologyStem Cell Research +7

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

Yue Huang, Rui Su, Yue Sheng, +25

Cancer Cell

Hematological MalignancyBiochemistryNatural SciencesAcute Myeloid LeukemiaMixed-phenotype Acute Leukemia +6

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Rui Su, Lei Dong, Yangchan Li, +36

Cancer Cell

Immune EvasionMedicineStem Cell MobilizationImmunologyStem Cell Research +6

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

Huilin Huang, Hengyou Weng, Keren Zhou, +39

Nature

Histone ModificationsChromatinTranscriptional RegulationChromatin StructureChromatin Remodeling +12

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

Chao Shen, Yue Sheng, Allen Zhu, +21

Cell stem cell

Systems BiologyMedicineAcute Myeloid LeukemiaMixed-phenotype Acute LeukemiaStem Cell Research +7

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

Ying Qing, Lei Dong, Lei Gao, +26

Molecular Cell

BiochemistryMedicineCatabolismMetabolic RemodelingCarbonyl Metabolism +6

METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis

Rui Su, Lei Dong, Yangchan Li, +29

Nature Cell Biology

Signaling PathwayTranslational BiologyCell RegulationMedicineNatural Sciences +8