Jacob R. Haling

Publications

1.6K

Citations

H-Index

2007

Active since

Affiliations

Genomics Institute of the Novartis Research Foundation(Current)

University of California San Diego

Mirati Therapeutics (United States)

Novartis (Switzerland)

Novartis (United States)

Jacob R. Haling is an author at Genomics Institute of the Novartis Research Foundation specializing in medicine, cell biology, and radiation oncology.

ORCID

Top concepts

MedicineCell BiologyTumor BiologyRadiation OncologyPharmacologyDrug DiscoveryCancer ResearchNatural SciencesOncologyCancer Biology

Publications per year

2007–2024

Publications

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

Jill Hallin, Vickie Bowcut, Andrew Calinisan et al. · Nature Medicine · 2022 · 465 citations

Medicine, Pharmacology, Pharmacotherapy +7

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Georgia Hatzivassiliou, Jacob R. Haling, Huifen Chen et al. · Nature · 2013 · 317 citations

Oncology, Medicine, Receptor Tyrosine Kinase +6

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling

Jacob R. Haling, Jawahar Sudhamsu, Ivana Yen et al. · Cancer Cell · 2014 · 247 citations · Full text

Braf-mek Complex, Signal Transduction, Signaling Pathway +7

β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation

Nicholas J. Anthis, Jacob R. Haling, Camilla L. Oxley et al. · Journal of Biological Chemistry · 2009 · 127 citations · Full text

Cell Adhesion, Talin-induced Integrin Activation, Molecular Biology +16

Talin-dependent integrin activation is required for fibrin clot retraction by platelets

Jacob R. Haling, Susan J. Monkley, David R. Critchley et al. · Blood · 2010 · 87 citations · Full text

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