John M. Ketcham

Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of <i>MTAP</i> -Deleted Cancers

Christopher R. Smith, Ruth Aranda, Thomas P. Bobinski et al. · Journal of Medicinal Chemistry · 2022 · 151 citations · Full text

Pharmacy, Oncology, Pharmacology +15

Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction

John M. Ketcham, Jacob R. Haling, Shilpi Khare et al. · Journal of Medicinal Chemistry · 2022 · 94 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

The tandem intermolecular hydroalkoxylation/claisen rearrangement

John M. Ketcham, Bérenger Biannic, Aaron Aponick · Chemical Communications · 2012 · 77 citations

Natural Sciences, Chemistry, Catalysis +10

Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C–C Bond Formation: Potency Does Not Confer Bryostatin-like Biology

John M. Ketcham, Te‐Yu Chen, Peter M. Blumberg et al. · Journal of the American Chemical Society · 2016 · 36 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

Controlling Regiochemistry in the Gold-Catalyzed Synthesis of Unsaturated Spiroketals

Paulo H. S. Paioti, John M. Ketcham, Aaron Aponick · Organic Letters · 2014 · 35 citations

Natural Sciences, Chemistry, Biocatalysis +16