Concepedia

Huifen Chen

HC

Statistics

Publications

70

Citations

4.3K

H-Index

34

Active since

1990

Affiliations

Chung Yuan Christian University(Current)

Pfizer (United States)

Gene Therapy Laboratory

Purdue University West Lafayette

Array BioPharma (United States)

Huifen Chen is an author at Chung Yuan Christian University specializing in pharmacology, drug discovery, and medicinal chemistry.

Publications per year

1990–2024

70

Publications

70

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky et al. · Nature Structural & Molecular Biology · 2004 · 621 citations

Life Sciences, Biochemistry, Molecular Biology +9

Ser <sup>1292</sup> Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

Zejuan Sheng, Shuo Zhang, Daisy Bustos et al. · Science Translational Medicine · 2012 · 375 citations

Medicine, Cell Biology, Pharmacology +10

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

Georgia Hatzivassiliou, Jacob R. Haling, Huifen Chen et al. · Nature · 2013 · 320 citations

Medicine, Cancer Biology, Oncology +14

ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors

Georgia Hatzivassiliou, Bonnie Liu, Carol O’Brien et al. · Molecular Cancer Therapeutics · 2012 · 209 citations · Full text

Medicine, Oncology, Pharmacology +17

Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Anthony A. Estrada, Xingrong Liu, Charles Baker‐Glenn et al. · Journal of Medicinal Chemistry · 2012 · 164 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

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