Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky, +19

Nature Structural & Molecular Biology

Signal TransductionSignaling PathwayCell RegulationReceptor Tyrosine KinaseMolecular Biology +6

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

Qing‐Jun Meng, Elizabeth S. Maywood, David A. Bechtold, +14

Proceedings of the National Academy of Sciences

Selective Inhibition of Casein Kinase 1ϵ Minimally Alters Circadian Clock Period

Kevin M. Walton, Katherine Fisher, David M. Rubitski, +18

Journal of Pharmacology and Experimental Therapeutics

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

J. Richard Miller, Steve Dunham, Igor Mochalkin, +27

Proceedings of the National Academy of Sciences

Drug TargetBioorganic ChemistryAntimicrobial ChemotherapyBc Active SiteDrug Resistance +17

The Structure of the Carboxyltransferase Component of Acetyl-CoA Carboxylase Reveals a Zinc-Binding Motif Unique to the Bacterial Enzyme^,

P.W. Bilder, Sandra Lightle, Graeme Bainbridge, +9

Biochemistry

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Joseph S. Warmus, Cathlin Flamme, Lu Yan Zhang, +15

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +7

Discovery of a Series of Imidazo[4,5-<i>b</i>]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ

Agustin Casimiro‐Garcia, Gary F. Filzen, Declan Flynn, +14

Journal of Medicinal Chemistry

4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase

Julie A. Spicer, Gordon W. Rewcastle, Michael D. Kaufman, +22

Journal of Medicinal Chemistry

Novel and selective spiroindoline-based inhibitors of sky kinase

Noel A. Powell, Jeffrey T. Kohrt, Kevin J. Filipski, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryMedicineReceptor Tyrosine KinaseMechanism Of Action +4

Characterization of substrate binding and catalysis in the potential antibacterial target <i>N</i>‐acetylglucosamine‐1‐phosphate uridyltransferase (GlmU)

Igor Mochalkin, Sandra Lightle, Yaqi Zhu, +6

Protein Science

GlycobiologyMolecular BiologyChemical BiologySubstrate BindingProtein X-ray Crystallography +14