Sandra Lightle

Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches

Igor Mochalkin, J. Richard Miller, Lakshmi Narasimhan et al. · ACS Chemical Biology · 2009 · 104 citations · Full text

Drug Target, Bioorganic Chemistry, Hit Identification +21

The Structure of the Carboxyltransferase Component of Acetyl-CoA Carboxylase Reveals a Zinc-Binding Motif Unique to the Bacterial Enzyme^,

P.W. Bilder, Sandra Lightle, Graeme Bainbridge et al. · Biochemistry · 2006 · 87 citations

Structural evidence for substrate‐induced synergism and half‐sites reactivity in biotin carboxylase

Igor Mochalkin, J. Richard Miller, A.G. Evdokimov et al. · Protein Science · 2008 · 85 citations · Full text

Crystal Structure, Engineering, Molecular Biology +18

Comparative functional characterization of canine IgG subclasses

Lisa M. Bergeron, Erin E. McCandless, Steve Dunham et al. · Veterinary Immunology and Immunopathology · 2013 · 77 citations

Biology, Comparative Functional Characterization, Working Dog +9

Crystal structure of LpxC from <i>Pseudomonas aeruginosa</i> complexed with the potent BB‐78485 inhibitor

Igor Mochalkin, John D. Knafels, Sandra Lightle · Protein Science · 2008 · 57 citations · Full text

Crystal Structure, Potent Bb‐78485 Inhibitor, Hydrophobic Anchor +19