Ser ¹²⁹² Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

Zejuan Sheng, Shuo Zhang, Daisy Bustos, +22

Science Translational Medicine

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Reina N. Fuji, Michael Flagella, Miriam Baca, +29

Science Translational Medicine

Disabled-2 Is Essential for Endodermal Cell Positioning and Structure Formation during Mouse Embryogenesis

Dong‐Hua Yang, Elizabeth R. Smith, Isabelle Roland, +6

Developmental Biology

Embryonic Stem CellDevelopmental BiologyCell SpecializationEndodermal Cell PositioningMedicine +7

Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Anthony A. Estrada, Xingrong Liu, Charles Baker‐Glenn, +36

Journal of Medicinal Chemistry

Small Molecule InhibitorsBroad Kinase SelectivityDrug TargetPharmaceutical ChemistryMedicinal Chemistry +17

Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Anthony A. Estrada, Bryan Chan, Charles Baker‐Glenn, +29

Journal of Medicinal Chemistry

Restoration of positioning control following Disabled-2 expression in ovarian and breast tumor cells

Zejuan Sheng, Wenping Sun, Elizabeth Smith, +3

Oncogene

Breast OncologySignal TransductionCell RegulationCell ControlGynecology +9

Differential Effects of Divalent Manganese and Magnesium on the Kinase Activity of Leucine-Rich Repeat Kinase 2 (LRRK2)

Brian Lovitt, Erica C. VanderPorten, Zejuan Sheng, +3

Biochemistry

MitophagyCellular PhysiologyDifferential EffectsReceptor Tyrosine KinaseAutophagy +16

Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor

Bryan Chan, Anthony A. Estrada, Huifen Chen, +21

ACS Medicinal Chemistry Letters

Medicinal ChemistryAniline BioisosteresBiochemistryLrrk2 InhibitorsMedicine +10

Synaptic Ca ²⁺ in Darkness Is Lower in Rods than Cones, Causing Slower Tonic Release of Vesicles

Zejuan Sheng, Sue‐Yeon Choi, Ajay Dharia, +3

Journal of Neuroscience

Structure, Sequence, and Promoter Analysis of Human Disabled-2 Gene (DAB2)

Zejuan Sheng, Junqi He, Joseph A. Tuppen, +5

Genomics

Promoter AnalysisGenetic DisorderNatural SciencesGeneticsMolecular Biology +5