Concepedia

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou, Kyung Song, Ivana Yen, Barbara J. Brandhuber, Daniel J. Anderson, Ryan Alvarado, Mary J. C. Ludlam, David Stokoe, Susan L. Gloor, Guy Vigers,

Nature · 2010 · 1.6K citations · 29 references

DOI

Concepts

References

29

The CCP4 suite: programs for protein crystallography

Number Collaborative Computational Project · Acta Crystallographica Section D Biological Crystallography · 1994 · 17.3K citations

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Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

Paul Wan, Mathew J. Garnett, S. Mark Roe et al. · Cell · 2004 · 2.8K citations · Full text

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Fluorescent proteins from nonbioluminescent Anthozoa species

Mikhail V. Matz, Arkady F. Fradkov, Yulii A. Labas et al. · Nature Biotechnology · 1999 · 1.8K citations

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai, John Tayu Lee, Weiru Wang et al. · Proceedings of the National Academy of Sciences · 2008 · 1.3K citations · Full text

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