Concepedia

Erk Signaling

ERK Signaling is a canonical intracellular signal transduction pathway within the mitogen-activated protein kinase (MAPK) cascade that propagates extracellular stimuli to the nucleus to regulate cell proliferation, differentiation, and survival through sequential phosphorylation of Raf, MEK, and ERK proteins.

12.7K

Publications

913.2K

Citations

64.2K

Authors

5.8K

Institutions

Publications per year

2017–2026

2.5K

Variants

Erk Pathway

Parents

Publications

12.7K

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Zhengui Xia, Martin Dickens, Joël Raingeaud et al. · Science · 1995 · 5.3K citations

, , +16

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Scott M. Wilhelm, Christopher Carter, LiYa Tang et al. · Cancer Research · 2004 · 4K citations · Full text

, , +17

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

Paul Wan, Mathew J. Garnett, S. Mark Roe et al. · Cell · 2004 · 2.8K citations · Full text

, , +14

MAP kinase signalling cascade in Arabidopsis innate immunity

Tsuneaki Asai, Guillaume Tena, Joulia Plotnikova et al. · Nature · 2002 · 2.8K citations

, , +14

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

David T. Dudley, Long Pang, Stuart J. Decker et al. · Proceedings of the National Academy of Sciences · 1995 · 2.7K citations · Full text

, , +15

1–5 of 12.7K

Authors

64.2K

  1. MH
    Melanie H. Cobb

    The University of Texas Southwestern Medical Center, United States

    58 publications · 12.1K citations

    47

    h-index

  2. RS
    Rony Seger

    Weizmann Institute of Science, Israel

    53 publications · 5.2K citations

    38

    h-index

  3. EN
    Eisuke Nishida

    Kyoto University, Japan

    39 publications · 6.3K citations

    34

    h-index

  4. WK
    Walter Kölch

    University College Dublin, Ireland

    42 publications · 7K citations

    32

    h-index

  5. ZD
    Zigang Dong

    Hormel (United States), United States

    43 publications · 3.6K citations

    31

    h-index

1–5 of 64.2K

Institutions

5.8K

  1. Harvard University

    Cambridge, United States

    111 h-index

    1.1K publications

    210.3K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    99 h-index

    483 publications

    131K citations

  3. Inserm

    Paris, France

    82 h-index

    1.1K publications

    84.6K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    79 h-index

    949 publications

    70.6K citations

  5. The University of Texas MD Anderson Cancer Center

    Houston, United States

    73 h-index

    695 publications

    86.6K citations

  6. University of California San Diego

    San Diego, United States

    69 h-index

    445 publications

    50.6K citations

  7. National Institutes of Health

    Bethesda, United States

    68 h-index

    638 publications

    72.4K citations

  8. The University of Texas Southwestern Medical Center

    Dallas, United States

    67 h-index

    410 publications

    56.2K citations

1–8 of 5.8K

Venues

  1. Journal of Biological Chemistry

    JBC · 1K publications · 105.1K citations

    164

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 185 publications · 31.5K citations

    101

    h-index

  3. Molecular and Cellular Biology

    MCB · 212 publications · 26.8K citations

    98

    h-index

  4. Journal of Neuroscience

    131 publications · 19.9K citations

    82

    h-index

  5. Cancer Research

    172 publications · 23.3K citations

    81

    h-index

1–5