Mary J. C. Ludlam

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou, Kyung Song, Ivana Yen et al. · Nature · 2010 · 1.6K citations

Medicine, Cancer Biology, Oncology +15

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Ingrid E. Wertz, Saritha Kusam, Cynthia Lam et al. · Nature · 2011 · 810 citations

Medicine, Molecular Biology, Oncology +7

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

Marcin Kowanetz, Xiumin Wu, Martha Tan et al. · Proceedings of the National Academy of Sciences · 2010 · 665 citations · Full text

Medicine, Cancer Biology, Oncology +13

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Till Maurer, Lindsay S. Garrenton, Angela Oh et al. · Proceedings of the National Academy of Sciences · 2012 · 630 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

H Zhang, J Chen, Sajid Khan Tahir et al. · Cell Death and Disease · 2015 · 429 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16