Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Till Maurer, Lindsay S. Garrenton, Angela Oh, +16

Proceedings of the National Academy of Sciences

Distinct PocketMolecular BiologyRas GeneSmall-molecule LigandsCancer Biology +19

Structural basis for dual-mode inhibition of the ABC transporter MsbA

Hoangdung Ho, Anh Miu, Mary Kate Alexander, +29

Nature

Molecular PharmacologySignal TransductionMolecular PhysiologyBiochemistryNatural Sciences +7

Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins

Wouter L. W. Hazenbos, Kimberly K. Kajihara, Richard Vandlen, +25

PLoS Pathogens

Microbial PathogensGlycobiologyImmunologyMolecular BiologyStaphylococcus Aureus +14

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p <i>K</i> _a Polar Moiety

Chudi Ndubaku, James J. Crawford, Joy Drobnick, +25

ACS Medicinal Chemistry Letters

Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Xiaozhang Zheng, Paul Bauer, Timm Baumeister, +24

Journal of Medicinal Chemistry

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

Joachim Rudolph, Lesley Murray, Chudi Ndubaku, +26

Journal of Medicinal Chemistry

Cardiovascular PharmacologyPharmacotherapyCardiovascular ToxicityDiverse GroupTumor Biology +16

Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

Mary Kate Alexander, Anh Miu, Angela Oh, +23

Antimicrobial Agents and Chemotherapy

The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site

G. de Leon-Boenig, Krista K. Bowman, Jianwen A. Feng, +11

Structure

Crystal StructureProtein FunctionSignal TransductionSignaling PathwayMolecular Pathway +10

Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Xiaozhang Zheng, Paul Bauer, Timm Baumeister, +19

Journal of Medicinal Chemistry

Drug TargetBiomolecular Structure PredictionPharmacotherapyChemical BiologyPharmaceutical Chemistry +21

Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors

Steven T. Staben, Jianwen A. Feng, Karen S. Lyle, +21

Journal of Medicinal Chemistry

Compound 17Structure-based MethodsKinase InhibitorsGroup Ii PaksChemical Biology +16