Richard Vandlen

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark et al. · Nature Biotechnology · 2008 · 1.3K citations

Medicinal Chemistry, Immunocytochemical Technique, Drug Targeting +10

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Ben‐Quan Shen, Keyang Xu, Luna Liu et al. · Nature Biotechnology · 2012 · 977 citations

Immunoengineering, Immunology, Bioconjugation +8

Identification of Heregulin, a Specific Activator of p185 ^erbB2

William E. Holmes, Mark X. Sliwkowski, Robert W. Akita et al. · Science · 1992 · 958 citations

Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

Sophie M. Lehar, Thomas H. Pillow, Min Xu et al. · Nature · 2015 · 815 citations

Antimicrobial Drug Discovery, Antimicrobial Susceptibility, Antibiotics +7

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

Mark X. Sliwkowski, Gabriele Schaefer, Robert W. Akita et al. · Journal of Biological Chemistry · 1994 · 643 citations · Full text

Breast Oncology, High Affinity Receptor, Immunology +20