Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

Sophie M. Lehar, Thomas H. Pillow, Min Xu, +29

Nature

Antimicrobial Drug DiscoveryAntimicrobial SusceptibilityAntibioticsMedicineMicrobiology +5

LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity

Akshay T. Krishnamurty, Justin A. Shyer, Minh Thai, +28

Nature

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters

Elena A. Dubikovskaya, Steve H. Thorne, Thomas H. Pillow, +2

Proceedings of the National Academy of Sciences

Multidrug ResistanceCell CulturePharmacotherapyTumor BiologyDrug Resistance +17

Antibody Conjugation of a Chimeric BET Degrader Enables <i>in vivo</i> Activity

Thomas H. Pillow, Pragya Adhikari, Robert A. Blake, +29

ChemMedChem

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy

Peter S. Dragovich, Thomas H. Pillow, Robert A. Blake, +34

Journal of Medicinal Chemistry

Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates

Leanna R. Staben, Stefan G. Koenig, Sophie M. Lehar, +20

Nature Chemistry

Medicinal ChemistryAntibody–drug ConjugatesDrug TargetingMedicineTargeted Drug Delivery +6

Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody–Drug Conjugates

Niña G. Caculitan, Josefa Chuh, Yong Ma, +12

Cancer Research

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties

Peter S. Dragovich, Thomas H. Pillow, Robert A. Blake, +34

Journal of Medicinal Chemistry

Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates

Thomas H. Pillow, Jack Sadowsky, Donglu Zhang, +10

Chemical Science

High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

Rachana Ohri, Sunil Bhakta, Aimee Fourie-O’Donohue, +17

Bioconjugate Chemistry

Molecular BiologyImmunochemistryAntibody EngineeringDisulfide-based LinkersVitro Plasma Stabilities +14