Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark, +28

Nature Biotechnology

Medicinal ChemistryImmunocytochemical TechniqueDrug TargetingTherapeutic IndexMedicine +8

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

Ben‐Quan Shen, Keyang Xu, Luna Liu, +30

Nature Biotechnology

ImmunoengineeringImmunologyBioconjugationAntibody EngineeringImmunotherapeutics +6

Molecular cloning and expression of a receptor for human tumor necrosis factor

Thomas J. Schall, Martyn Lewis, Kerry J. Koller, +9

Cell

InflammationCytokineDisease MechanismApoptosisReceptor (Biochemistry) +6

Identification of Heregulin, a Specific Activator of p185 ^erbB2

William E. Holmes, Mark X. Sliwkowski, Robert W. Akita, +12

Science

Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

Sophie M. Lehar, Thomas H. Pillow, Min Xu, +29

Nature

Antimicrobial Drug DiscoveryAntimicrobial SusceptibilityAntibioticsMedicineMicrobiology +5

Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

Jagath R. Junutula, Kelly M. Flagella, Richard Graham, +17

Clinical Cancer Research

Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection

Andrew G. Polson, Jill Calemine-Fenaux, Pamela Chan, +26

Cancer Research

ImmunologyChemical LinkersImmunotherapeuticsImmunotherapyTumor Biology +15

Reevaluation of the roles of protein S and gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3

Paul J. Godowski, Melanie R. Mark, Jian Chen, +3

Cell

Signal TransductionMolecular PhysiologyBiochemistryG Protein-coupled ReceptorNatural Sciences +9

Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry

Keyang Xu, Luna Liu, Ola M. Saad, +8

Analytical Biochemistry

MedicineIntact Antibody–drug ConjugatesBioanalysisMass SpectrometryImmunology +9

Comprehensive Analysis of the Factors Contributing to the Stability and Solubility of Autonomous Human VH Domains

Pierre A. Barthelemy, Helga Raab, B.A. Appleton, +4

Journal of Biological Chemistry