Joy Drobnick

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR

Timothy P. Heffron, Chudi Ndubaku, Laurent Salphati et al. · ACS Medicinal Chemistry Letters · 2016 · 104 citations · Full text

Pi3k Inhibitors, Chemoprevention Strategy, Poor Metabolic Stability +18

Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques

Paola Di Lello, Richard Pastor, Jeremy Murray et al. · Journal of Medicinal Chemistry · 2017 · 86 citations · Full text

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p <i>K</i> _a Polar Moiety

Chudi Ndubaku, James J. Crawford, Joy Drobnick et al. · ACS Medicinal Chemistry Letters · 2015 · 81 citations · Full text

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

Joachim Rudolph, Lesley Murray, Chudi Ndubaku et al. · Journal of Medicinal Chemistry · 2016 · 74 citations · Full text

Cardiovascular Pharmacology, Pharmacotherapy, Cardiovascular Toxicity +18

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis

Chudi Ndubaku, Terry D. Crawford, Huifen Chen et al. · ACS Medicinal Chemistry Letters · 2015 · 44 citations · Full text

Ocular Disease, Medicinal Chemistry, Angiogenesis +21