USP7 small-molecule inhibitors interfere with ubiquitin binding

Lorna Kategaya, Paola Di Lello, Lionel Rougé, +41

Nature

Molecular DockingUbiquitin BindingDrug TargetMedicineNatural Sciences +5

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

Alexander M. Taylor, Alexandre Côté, Michael C. Hewitt, +41

ACS Medicinal Chemistry Letters

Drug TargetChemical BiologyCancer BiologyMedicinal ChemistryAnti-cancer Agent +14

Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques

Paola Di Lello, Richard Pastor, Jeremy Murray, +13

Journal of Medicinal Chemistry

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

Michael Siu, Richard Pastor, Wendy Liu, +22

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryJak2 InhibitorsMedicinePharmacological AgentPharmacotherapy +5

Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)

Zhonghua Pei, Rohan Mendonca, Lewis Gazzard, +13

ACS Medicinal Chemistry Letters

Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors

Brendan T. Parr, Richard Pastor, Benjamin D. Sellers, +27

ACS Medicinal Chemistry Letters

Tricyclic HIV integrase inhibitors: Potent and orally bioavailable C5-aza analogs

Haolun Jin, Matthew Wright, Richard Pastor, +9

Bioorganic & Medicinal Chemistry Letters

PharmacologyBioavailable C5-aza AnalogsAntiviral Drug DevelopmentAntiviral TherapyAntiviral Drug +4

Optimization of globomycin analogs as novel gram-negative antibiotics

Keira Garland, Homer Pantua, M. Braun, +20

Bioorganic & Medicinal Chemistry Letters

Globomycin AnalogsAntibioticsMedicineAntimicrobial ChemotherapyAntimicrobial Compound +4

Synthesis of 1-amino-2-vinylcyclopropane-1-phosphinates. Conversion of a phosphonate to phosphinates

Hyung‐Jung Pyun, Michael O. Clarke, Aesop Cho, +6

Tetrahedron Letters

Organic ChemistrySynthetic ChemistryChemistry