Richard Pastor

USP7 small-molecule inhibitors interfere with ubiquitin binding

Lorna Kategaya, Paola Di Lello, Lionel Rougé et al. · Nature · 2017 · 332 citations · Full text

Molecular Docking, Ubiquitin Binding, Drug Target +7

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

Alexander M. Taylor, Alexandre Côté, Michael C. Hewitt et al. · ACS Medicinal Chemistry Letters · 2016 · 111 citations · Full text

Drug Target, Chemical Biology, Cancer Biology +16

Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques

Paola Di Lello, Richard Pastor, Jeremy Murray et al. · Journal of Medicinal Chemistry · 2017 · 86 citations · Full text

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

Michael Siu, Richard Pastor, Wendy Liu et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 44 citations · Full text

Medicinal Chemistry, Jak2 Inhibitors, Medicine +7

Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)

Zhonghua Pei, Rohan Mendonca, Lewis Gazzard et al. · ACS Medicinal Chemistry Letters · 2018 · 39 citations · Full text