Concepedia

Author

Lewis Gazzard

Charles River Laboratories (United Kingdom)ORCID

Also Known As

Gazzard, L., Gazzard, Lewis, L. GAZZARD, L. Gazzard, Lewis Gazzard, Lewis J. Gazzard

66

Publications

1.1K

Citations

16

H-Index

36

Concepts

All Affiliations

Charles River Laboratories (United Kingdom)The University of Texas at AustinGenesys (United States)Shanghai Zhangjiang Laboratory
LG

About

Lewis Gazzard is an author at Charles River Laboratories (United Kingdom) specializing in medicine, pharmacology, and drug discovery.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

9

9

569

2

Natural Sciences

5

5

394

3

Biochemistry

4

4

126

4

Engineering

3

3

120

5

Cell Biology

1

1

36

Lewis Gazzard

×

19

Publications

1.1K

Citations

16

H-Index

YearCitations

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

John A. Flygare, Maureen H. Beresini, Nageshwar Budha,

Journal of Medicinal Chemistry

2012

247

Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody–drug conjugates

Cary D. Austin, Xiaohui Wen, Lewis Gazzard,

Proceedings of the National Academy of Sciences

2005

235

Synthesis of the Kopsia alkaloids (±)-pauciflorine B, (±)-lahadinine B, (±)-kopsidasine, (±)-kopsidasine-N-oxide, (±)-kopsijasminilam and (±)-11-methoxykopsilongine

Philip Magnus, Lewis Gazzard, L. Hobson,

Tetrahedron

2002

88

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-p <i>K</i> <sub>a</sub> Polar Moiety

Chudi Ndubaku, James J. Crawford, Joy Drobnick,

ACS Medicinal Chemistry Letters

2015

81

Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window

Joachim Rudolph, Lesley Murray, Chudi Ndubaku,

Journal of Medicinal Chemistry

2016

74

Identifying transcriptional programs underlying cancer drug response with TraCe-seq

Matthew T. Chang, Thi Thu Thao Nguyen, Steven T. Staben,

Nature Biotechnology

2021

54

Preparation of 1-fluoroglycosides from 1-arylthio and 1-arylselenoglycosides using 4-methyl(difluoroiodo)benzene

Stephen Caddick, Lewis Gazzard, William B. Motherwell,

Tetrahedron

1996

47

Rhodium promoted isomerisation of allylic alkoxides: a new method for enolate anion formation

Lewis Gazzard, William B. Motherwell, David A. Sandham

Journal of the Chemical Society Perkin Transactions 1

1999

42

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1)

Bryan Chan, Eileen M. Seward, Michael Lainchbury,

ACS Medicinal Chemistry Letters

2021

42

Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)

Zhonghua Pei, Rohan Mendonca, Lewis Gazzard,

ACS Medicinal Chemistry Letters

2018

39

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