John A. Flygare

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Eugene Varfolomeev, John W. Blankenship, Sarah M. Wayson et al. · Cell · 2007 · 1.2K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

Sophie M. Lehar, Thomas H. Pillow, Min Xu et al. · Nature · 2015 · 833 citations

Pharmacy, Infectious Diseases, Microbiology +10

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

Helena Mancebo, Gary Lee, John A. Flygare et al. · Genes & Development · 1997 · 542 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +13

Structure-guided design of a selective BCL-XL inhibitor

Guillaume Lessène, Peter E. Czabotar, Brad E. Sleebs et al. · Nature Chemical Biology · 2013 · 374 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of a Potent and Selective BCL-X _L Inhibitor with <i>in Vivo</i> Activity

Zhi‐Fu Tao, Lisa Hasvold, Le Wang et al. · ACS Medicinal Chemistry Letters · 2014 · 331 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10