USP7 small-molecule inhibitors interfere with ubiquitin binding

Lorna Kategaya, Paola Di Lello, Lionel Rougé, +41

Nature

Molecular DockingUbiquitin BindingDrug TargetMedicineNatural Sciences +5

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

Bradford Graves, Thelma Thompson, Mingxuan Xia, +12

Proceedings of the National Academy of Sciences

Dimeric Protein ComplexesMolecular BiologyMdmx DimerizationCancer BiologyAnti-cancer Agent +14

Structure of the Tfb1/p53 Complex: Insights into the Interaction between the p62/Tfb1 Subunit of TFIIH and the Activation Domain of p53

Paola Di Lello, Lisa M. Jenkins, Tamara Jones, +7

Molecular Cell

Activation DomainP62/tfb1 SubunitMolecular BiologyTfb1/p53 ComplexMolecular Basis +5

An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

Thijs J. Hagenbeek, Marc Hafner, Rana Mroue, +38

Nature Cancer

Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

Yingnan Zhang, Charles Eigenbrot, Lijuan Zhou, +10

Journal of Biological Chemistry

Signal TransductionBiochemistryPeptide LibraryImmunologySmall Peptide +4

Molecular Understanding of USP7 Substrate Recognition and C-Terminal Activation

Lionel Rougé, Travis W. Bainbridge, Michael C. M. Kwok, +6

Structure

Usp7 Substrate RecognitionProtein FunctionBiochemistryNatural SciencesSignal Recognition +3

Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques

Paola Di Lello, Richard Pastor, Jeremy Murray, +13

Journal of Medicinal Chemistry

Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists

Yingnan Zhang, Mark Ultsch, Nicholas J. Skelton, +13

Nature Structural & Molecular Biology

Signal TransductionBiochemistryNatural SciencesPeptide EngineeringPeptide Library +6

Crystal Structures of the Organomercurial Lyase MerB in Its Free and Mercury-bound Forms

Julien Lafrance‐Vanasse, M. Lefebvre, Paola Di Lello, +2

Journal of Biological Chemistry

X-ray CrystallographyCrystal StructureStructural BioinformaticsBiomolecular Structure PredictionMolecular Biology +17

A Stable Mercury-Containing Complex of the Organomercurial Lyase MerB:  Catalysis, Product Release, and Direct Transfer to MerA

Gregory Benison, Paola Di Lello, Jacob E. Shokes, +4

Biochemistry

Bioorganic ChemistryOrganic ChemistryCysteine LigandChemistryChemical Biology +14