Lionel Rougé

Optimized arylomycins are a new class of Gram-negative antibiotics

Peter A. Smith, Michael F. T. Koehler, Hany S. Girgis et al. · Nature · 2018 · 348 citations

Antibiotics, Medicine, New Class +6

USP7 small-molecule inhibitors interfere with ubiquitin binding

Lorna Kategaya, Paola Di Lello, Lionel Rougé et al. · Nature · 2017 · 332 citations · Full text

Molecular Docking, Ubiquitin Binding, Drug Target +7

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

Jasvinder K. Atwal, Yongmei Chen, Cecilia Chiu et al. · Science Translational Medicine · 2011 · 275 citations

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

Daniel P. Sutherlin, Linda Bao, Megan Berry et al. · Journal of Medicinal Chemistry · 2011 · 212 citations · Full text

Translational Pharmacology, Pre-clinical Pharmacology, Molecular Pharmacology +20

Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell–cell adhesion and signaling mechanism that requires <i>cis-trans</i> receptor clustering

Katharina Stengel, Kristin Harden-Bowles, Xin Yu et al. · Proceedings of the National Academy of Sciences · 2012 · 206 citations · Full text