Susan L. Gloor

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou, Kyung Song, Ivana Yen et al. · Nature · 2010 · 1.6K citations · Full text

Signaling Pathway, Receptor Tyrosine Kinase, Mapk Pathway +8

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

James F. Blake, Rui Xu, Josef R. Bencsik et al. · Journal of Medicinal Chemistry · 2012 · 184 citations · Full text

Human Tumors, Tumor Biology, Medicinal Chemistry +15

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

Kui Lin, Jie Lin, Wen‐I Wu et al. · Science Signaling · 2012 · 166 citations

Molecular Biology, Conformational Changes, Substantial Conformational Change +16

Use of Site‐Directed Cysteine and Disulfide Chemistry to Probe Protein Structure and Dynamics: Applications to Soluble and Transmembrane Receptors of Bacterial Chemotaxis

Randal B. Bass, Scott L. Butler, Stephen A. Chervitz et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 2007 · 86 citations · Full text

Proteinlipid Interaction, Protein Assembly, Biochemistry +8

Pyrazolopyridine Inhibitors of B-Raf^V600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors

Steve Wenglowsky, Li Ren, Kateri A. Ahrendt et al. · ACS Medicinal Chemistry Letters · 2011 · 66 citations · Full text