Susan L. Gloor

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou, Kyung Song, Ivana Yen et al. · Nature · 2010 · 1.6K citations

Medicine, Cancer Biology, Oncology +15

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

James F. Blake, Rui Xu, Josef R. Bencsik et al. · Journal of Medicinal Chemistry · 2012 · 188 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

Kui Lin, Jie Lin, Wen‐I Wu et al. · Science Signaling · 2012 · 171 citations

Life Sciences, Biochemistry, Molecular Biology +17

Use of Site‐Directed Cysteine and Disulfide Chemistry to Probe Protein Structure and Dynamics: Applications to Soluble and Transmembrane Receptors of Bacterial Chemotaxis

Randal B. Bass, Scott L. Butler, Stephen A. Chervitz et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 2007 · 86 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Pyrazolopyridine Inhibitors of B-Raf^V600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors

Steve Wenglowsky, Li Ren, Kateri A. Ahrendt et al. · ACS Medicinal Chemistry Letters · 2011 · 66 citations · Full text

Medicine, Oncology, Pharmacology +15