Kui Lin

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

Kui Lin, Honor Hsin, Natasha Libina et al. · Nature Genetics · 2001 · 1K citations

Life Sciences, Biology, Genetics +12

Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models

Jie Lin, Deepak Sampath, Michelle Nannini et al. · Clinical Cancer Research · 2013 · 295 citations

Medicine, Oncology, Pharmacology +16

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

James F. Blake, Rui Xu, Josef R. Bencsik et al. · Journal of Medicinal Chemistry · 2012 · 188 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

Kui Lin, Jie Lin, Wen‐I Wu et al. · Science Signaling · 2012 · 171 citations

Life Sciences, Biochemistry, Molecular Biology +17

A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors

Cristina Saura, Desamparados Roda, Susana Roselló et al. · Cancer Discovery · 2016 · 171 citations · Full text

Medicine, Oncology, Pharmacology +14