Karen O’Rourke - Concepedia

Author

Karen O’Rourke

Also Known As

K M O'Rourke, K O'Rourke, K O’Rourke, K. O'Rourke, K. O’Rourke, K.M. O'Rourke, Karen M. O'Rourke, Karen M. O’Rourke, Karen O'Rourke, Karen O’Rourke

Publications

28.9K

Citations

H-Index

Concepts

All Affiliations

University of Michigan Molecular Oncology (United States)Garvan Institute of Medical Research Australian National University Duke University Hospital

About

Karen O’Rourke is an author at University of Michigan specializing in medicine, cell biology, and cell signaling.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	28	29	21.5K
2	Cell Biology	25	26	21.1K
3	Natural Sciences	14	14	12.2K
4	Cellular Physiology	6	6	4K
5	Biochemistry	4	4	3.4K

Karen O’Rourke

Publications

28.7K

Citations

H-Index

Page 1

	Year	Citations
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling Nobuhiko Kayagaki, Irma B. Stowe, Bettina L. Lee, Nature InflammationAnti-inflammatorySignal TransductionImmunologyChronic Inflammation	2015	3.5K
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex Marta Muzio, Arul M. Chinnaiyan, Frank Kischkel, Cell Death-inducing Signaling ComplexSignal TransductionSignaling PathwayProtein FunctionMedicine	1996	3K
Cryopyrin activates the inflammasome in response to toxins and ATP Sanjeev Mariathasan, David S. Weiss, Kim Newton, Nature Cell PhysiologyReductive StressSignal TransductionBiochemistryNatural Sciences	2006	3K
FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis Arul M. Chinnaiyan, Karen O’Rourke, Muneesh Tewari, Cell MitophagyProtein FunctionSignal TransductionSignaling PathwayMedicine	1995	2.4K
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase Muneesh Tewari, Long T. Quan, Karen O’Rourke, Cell Mammalian HomologProtein FunctionProtein ExpressionMedicineNatural Sciences	1995	2.4K
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling Ingrid E. Wertz, Karen O’Rourke, Honglin Zhou, Nature Signal TransductionCell RegulationMolecular PathwayMolecular RegulationSignaling Pathway	2004	1.8K
The Receptor for the Cytotoxic Ligand TRAIL Guohua Pan, Karen O’Rourke, Arul M. Chinnaiyan, Science	1997	1.8K
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 Ingrid E. Wertz, Saritha Kusam, Cynthia Lam, Nature Protein FunctionMedicineImmune Checkpoint InhibitorCancer BiologyCytoskeleton	2011	806
FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis Arul M. Chinnaiyan, Clifford G. Tepper, Michael F. Seldin, Journal of Biological Chemistry	1996	773
NINJ1 mediates plasma membrane rupture during lytic cell death Nobuhiko Kayagaki, Opher S. Kornfeld, Bettina L. Lee, Nature Reactive Nitrogen SpecieNitrosative StressCell DeathPlasma Membrane RuptureCellular Biochemistry	2021	737

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