Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag, Peter Hirth, James Tsai, +37

Nature

Skin CancerMedicineMelanomaClinical EfficacyPharmacology +5

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai, John Tayu Lee, Weiru Wang, +35

Proceedings of the National Academy of Sciences

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

Yasunori Kasahara, Rubin M. Tuder, Laimute Taraseviciene‐Stewart, +5

Journal of Clinical Investigation

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

Moosa Mohammadi, Gerald McMahon, Li Sun, +5

Science

Molecular BiologyCell GrowthSignaling PathwayReceptor Tyrosine KinaseFibroblast Growth Factor +15

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death‐dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

Laimute Taraseviciene‐Stewart, Yasunori Kasahara, Lori Alger, +5

The FASEB Journal

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

William D. Tap, Zev A. Wainberg, Stephen P. Anthony, +37

New England Journal of Medicine

Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones:  A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Flora Tang, +4

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBiochemistryRtk ActivityMedicine +12

RAF inhibitors that evade paradoxical MAPK pathway activation

Chao Zhang, Wayne Spevak, Ying Zhang, +32

Nature

Signaling PathwayMedicineReceptor Tyrosine KinaseMechanism Of ActionRaf Inhibitors +3

Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor

Chao Zhang, Prabha N. Ibrahim, Jiazhong Zhang, +24

Proceedings of the National Academy of Sciences

Drug TargetSpecific Dual FmsImmunologyPharmacotherapyImmunotherapy +21

Pharmacodynamic Characterization of the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant Melanoma

William D. Tap, Ke-Wei Gong, Judy Daring, +9

Neoplasia