Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A. Barbie, Pablo Tamayo, Jesse S. Boehm, +32

Nature

Systems BiologyOncogenic AgentMedicineKras-driven CancersCancer Biology +2

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

J.M. Ostrem, Ulf Peters, Martin L. Sos, +2

Nature

Molecular PharmacologySignal TransductionG Protein-coupled ReceptorMedicineFunctional Selectivity +5

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Martin Peifer, Lynnette Fernandez‐Cuesta, Martin L. Sos, +89

Nature Genetics

EngineeringSomatic VariantTumor HeterogeneityMedicineGenetics +8

Frequent and Focal <i>FGFR1</i> Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

Jonathan M. Weiss, Martin L. Sos, Danila Seidel, +59

Science Translational Medicine

MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition

Gürkan Mollaoglu, Matthew R. Guthrie, Stefanie Böhm, +26

Cancer Cell

Variant Neuroendocrine SubtypeAurora Kinase InhibitionOncogenic AgentMedicineBronchial Neoplasm +7

Optimization of Dosing for EGFR-Mutant Non–Small Cell Lung Cancer with Evolutionary Cancer Modeling

Juliann Chmielecki, Jasmine Foo, Geoffrey R. Oxnard, +18

Science Translational Medicine

<i>PTEN</i> Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR

Martin L. Sos, Mirjam Koker, Barbara A. Weir, +19

Cancer Research

Egfr-mutant Lung CancerPten LossCancer BiologyTumor BiologyClinical Resistance +14

Mutations in the <i>DDR2</i> Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Peter S. Hammerman, Martin L. Sos, Alex H. Ramos, +53

Cancer Discovery

Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation

Helga B. Salvesen, Scott L.b Carter, Monica Mannelqvist, +19

Proceedings of the National Academy of Sciences

Pik3ca AmplificationEngineeringPathologyCancer BiologyTumor Biology +16

A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1

Nicholas T. Hertz, Amandine Berthet, Martin L. Sos, +4

Cell

Neurodegenerative DiseasesSignal TransductionMolecular NeuroscienceAmplifies Catalytic ActivitySignaling Pathway +8