Shaoyong Lu

Identification of a cellularly active SIRT6 allosteric activator

Zhimin Huang, Junxing Zhao, Wei Deng et al. · Nature Chemical Biology · 2018 · 257 citations

Signal Transduction, Molecular Regulation, Cellular Biochemistry +3

Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

Shaoyong Lu, Xinheng He, Zhao Yang et al. · Nature Communications · 2021 · 214 citations · Full text

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B

Shaoyong Lu, Hyunbum Jang, Ruth Nussinov et al. · Scientific Reports · 2016 · 212 citations · Full text

Allosite: a method for predicting allosteric sites

Wenkang Huang, Shaoyong Lu, Zhimin Huang et al. · Bioinformatics · 2013 · 210 citations · Full text

Allosteric Modulator Discovery: From Serendipity to Structure-Based Design

Shaoyong Lu, Xinheng He, Duan Ni et al. · Journal of Medicinal Chemistry · 2019 · 161 citations · Full text

Allosteric Modulators, Drug Target, Engineering +17