Xinheng He

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody

Wanchao Yin, Youwei Xu, Peiyu Xu et al. · Science · 2022 · 299 citations · Full text

Virus Structure, Viral Evolution, Omicron Spike Trimer +10

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor

Youwen Zhuang, Yue Wang, Bingqing He et al. · Cell · 2022 · 227 citations

Opioid Epidemic, Molecular Pharmacology, Health Sciences +14

Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

Jia Duan, Dandan Shen, X. Edward Zhou et al. · Nature Communications · 2020 · 218 citations · Full text

Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

Shaoyong Lu, Xinheng He, Zhao Yang et al. · Nature Communications · 2021 · 214 citations · Full text

Allosteric Modulator Discovery: From Serendipity to Structure-Based Design

Shaoyong Lu, Xinheng He, Duan Ni et al. · Journal of Medicinal Chemistry · 2019 · 161 citations · Full text

Allosteric Modulators, Drug Target, Engineering +17