Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody

Wanchao Yin, Youwei Xu, Peiyu Xu, +22

Science

Virus StructureViral EvolutionOmicron Spike TrimerAnti-omicron AntibodyViral Pathogenesis +8

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor

Youwen Zhuang, Yue Wang, Bingqing He, +20

Cell

Opioid EpidemicMolecular PharmacologyHealth SciencesBiochemistryAddiction +12

Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

Jia Duan, Dandan Shen, X. Edward Zhou, +13

Nature Communications

Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

Shaoyong Lu, Xinheng He, Zhao Yang, +8

Nature Communications

Allosteric Modulator Discovery: From Serendipity to Structure-Based Design

Shaoyong Lu, Xinheng He, Duan Ni, +1

Journal of Medicinal Chemistry

Allosteric ModulatorsDrug TargetEngineeringMolecular BiologyAllosteric Modulator Discovery +15

Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy

Duan Ni, Jiacheng Wei, Xinheng He, +6

Chemical Science

Structures of full-length glycoprotein hormone receptor signalling complexes

Jia Duan, Peiyu Xu, Xi Cheng, +12

Nature

Signal TransductionMolecular PhysiologyG Protein-coupled ReceptorHormonal ReceptorReceptor (Biochemistry) +4

GPCR activation and GRK2 assembly by a biased intracellular agonist

Jia Duan, Heng Liu, Fenghui Zhao, +15

Nature

Molecular PharmacologySignal TransductionMolecular PhysiologySignaling PathwayG Protein-coupled Receptor +9

Ab initio characterization of protein molecular dynamics with AI2BMD

Tong Wang, Xinheng He, Mingyu Li, +12

Nature

Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor

Qiufeng Liu, Dehua Yang, Youwen Zhuang, +13

Nature Chemical Biology